The increasing development and installation of automatic data processing systems to support functional applications that may be similar in two or more major Army commands raised a need for better central planning and control. To satisfy that need, the U.S. Army Computer Systems Command (USACSC) was activated at Fort Belvoir, Virginia, on March 31, 1969. The command was designated a class II activity under the jurisdiction of the Assistant Vice Chief of Staff. It was assigned responsibility for development, installation, improvement, and other related support functions for Army multicommand automatic data processing systems, and will perform project management for assigned systems in response to functional requirements formulated by headquarters staff agencies. The command will insure effective communications planning and support for such systems and will conduct software research programs in co-ordination with the Chief of Research and Development.

Late in fiscal year 1968 the Directorate of Management Information Systems in the Office of the Assistant Vice Chief of Staff completed a study which revealed that certain organizational realignments at Headquarters, Department of the Army, level would benefit the Army's approach to information systems design and promote a more effective use of automatic data processing equipment. Thus in July 1968 the responsibilities assigned to the Director of Automatic Data Processing in the Office of the Comptroller of the Army were transferred to the management information systems directorate, including jurisdiction over the Computer Systems Evaluation Command. The latter was redesignated as the Computer Systems Support and Evaluation Command and was made a class II activity under the directorate. As a result of this realignment, the management information systems directorate is now able to monitor, on an Army-wide basis, the design of information systems and the use of associated automatic data processing equipment. The directorate also has the professional capability to evaluate and select computers for all elements of the Army and provide a single point of contact with industry in this field.

On 15 May 1984, the United States Army Communications Command (USACC), a major command (MACOM) of the U.S. Army, was redesignated the United States Army Information Systems Command (USAISC). It was given the mission to manage the Information Mission Area (IMA), which was to place the responsibility for all areas of information management within the U.S. Army under one command. On the same date, the U.S. Army Computer Systems Command (USACSC), a field operating activity of the Headquarters, Department of the Army Assistant Deputy Chief of Staff for Operations-Command, Control, Communications, and Computers (C4), located at Fort Belvoir, Virginia, was transferred to the USAISC as a major subordinate command (MSC). Both of these actions were authorized by Department of the Army General Order No. 26, dated 25 July 1984.

On 1 October 1984, the USACSC was redesignated the U.S. Army Information Systems Software Support Command (USAISSSC) by USAISC Permanent Orders 42-1, dated 14 September 1984. Nine months later, the USAISSSC was redesignated the U.S. Army Information Systems Engineering Command (USAISEC) by USAISC Permanent Order 79-1, dated 1 July 85, and has retained this designation to the present day.